Many people who have osteoarthritis or rheumatoid arthritis regularly take non-steroidal anti-inflammatory drugs (NSAIDs) in order to reduce pain or inflammation in the joints. Commonly used NSAIDs include acetylsalicylic acid (the drug in medicines like Aspirin), ibuprofen, diclofenac and naproxen.
Nausea and vomiting often seen in patients with renal colic may cause dehydration which will further contribute to renal impairment. The risk of acute renal injury increases with decreased selectivity; COX II inhibitors have the lowest risk followed by diclofenac, ibuprofen, naproxen, indomethacin and ketorolac respectively .Diclofenac sodium, the medicine in Diclofenac Sodium Topical Gel, 1%, is a nonsteroidal anti-inflammatory drug (NSAID). NSAIDs are used to treat pain from medical conditions such as arthritis. Diclofenac Sodium Topical Gel, 1% works similarly to oral NSAIDs like ibuprofen or naproxen by temporarily blocking the production of pain signaling
Surprisingly, ibuprofen has a lower risk of GI bleeding, but it’s possible with both medications. Even though meloxicam is a preferential NSAID, one analysis found that the risk for GI bleeding is generally higher with meloxicam than ibuprofen. Researchers don’t know why meloxicam has greater GI risks than ibuprofen.Diclofenac and ibuprofen showed distinct antibacterial activity against E. faecalis in 50 μg/ml and above concentrations. Conclusion: Within the limitations of this in vitro study, it is concluded that diclofenac and ibuprofen have significantly more pronounced antibacterial activity against E. faecalis in comparison with Ca(OH) 2 .
People who have already had a heart attack or stroke must use NSAIDs with caution. One study showed that even one or two doses of ibuprofen or diclofenac (another NSAID) increased the risk of another event. During the 14 weeks of the study, naproxen did not appear to increase this risk.
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